| Abstract Objective To investigate the way of content construction related to periodical work by using WeChat official. .Methods The Wechat messages published on the Wechat service account of International Journal of Laboratory Medicine from July 1, 2017 to June 30, 2019 were selected as the research objects. According to the adjustment of Wechat content, it could be divided into before and after the adjustment. The number of Wechat messages published, the number of headlines, the number of original work, the number of reading, the number of likes, the number of comments, the number of fans' attention and other basic information were counted, and the number of reading of different columns before and after the adjustment was compared and analyzed. Results The results of statistical test showed that the number of reading, the number of likes and the number of comments of published Wechat messages before the adjustment were higher than those after the adjustment, and the differences were statistically significant (Z = －7.646,－7.712,－6.169, P = 0.000, 0.000, 0.000). The proportion of Wechat messages related to periodical work after the adjustment was higher than that before the adjustment (18.8% vs. 84.4%, x2=121.407, P=0.000). There was a significant difference in the constituent ratio of reading volume before and after the adjustment (x2 = 50.007, P = 0.000). Conclusion While Wechat platform is used for the content construction related to periodical work, the release frequency, quality and diversity of hot sci-tech articles in the industry should be paid attention to, it could maintain users’ activity, increase users’ viscosity, and achieve the balance of serving both journals and users.